The only way to instantly incapacitate an attacker with a handgun, is to hit the central nervous system. A head shot is a much smaller target than the torso, and the spinal cord is about the width of a pencil. These are challenging targets at 10 feet or farther, even when you're shooting at paper or steel targets that don't move or shoot back. Which is why most shooters train to aim for center mass. The most reliable mechanism by which a handgun bullet incapacitates an assailant shot in the torso (or extremeties), is rapid blood loss. The loss of roughly 20% of a person's total blood volume causes loss of consciousness. There are other effects that are somewhat controversial, like hydrostatic shock, and the psychological power of being shot, etc. But, if you drill enough holes in an attacker, you can rely on him bleeding out rapidly, even if you don't hit his heart or a lung and take the wind out of him.
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